Image microarrays derived from tissue microarrays (IMA-TMA): New resource for computer-aided diagnostic algorithm development
نویسندگان
چکیده
منابع مشابه
Image microarrays (IMA): Digital pathology's missing tool
INTRODUCTION The increasing availability of whole slide imaging (WSI) data sets (digital slides) from glass slides offers new opportunities for the development of computer-aided diagnostic (CAD) algorithms. With the all-digital pathology workflow that these data sets will enable in the near future, literally millions of digital slides will be generated and stored. Consequently, the field in gen...
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Computer-Aided Diagnosis (CAD) systems for pathologists can act as an intelligent digital assistant supporting automated grading and morphometric-based discovery of tissue features that are important in cancer diagnosis and patient prognosis. Automated image segmentation is an essential component of computer-based grading in CAD. We describe a novel tissue segmentation algorithm using local fea...
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BACKGROUND TMAs are becoming a useful tool for research and quality control methods, mostly for immunohistochemistry and in situ hybridization. METHODS A new technique that allows building TMA blocks with more than 300 tissue cores without using a recipient paraffin block for the tissue cores and without using a commercial TMA builder instrument is described. This technique is based on the co...
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Microarray technology is a powerful tool for generating expression data on a large number of genes simultaneously. However, as for any assay, it must be reproducible to give confidence in the results. Using a classical statistical method--the factorial design of experiments--we have assessed the effects of different experimental factors in our system. Significant effects on signal were seen whe...
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The TMA is a high-throughput technique to assess thousands of different cores of pathological tissue simultaneously using morphological and molecular analyses, e.g. immunohistochemistry and in situ hybridization, whilst maintaining an accurate and efficient method of identifying each specific section. Using this technique an economy in cutting and staining can also be used, with an unprecedente...
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ژورنال
عنوان ژورنال: Journal of Pathology Informatics
سال: 2012
ISSN: 2153-3539
DOI: 10.4103/2153-3539.98168